Bioavailability Study of Indomethacin Self-nanemulsifying Oral Formulation in Rats
نویسندگان
چکیده
In the present s tudy, a new self-nanoemuls ified drug delivery formulation (SNEDDF) of indomethacin (IND) was tes ted in rats for its in viv o p e rformance. Pharmacokinetic s tudies of IND SNEDDF was carried out after oral adminis tration of the prepared formulation (capsules) and compared with that of orally adminis tered IND oily solution (filled in capsule). From the pharmacokinetic p a ra me t ers , it was found that IND SNEDD capsules have improved bioavailability max over IND oily solution capsules . T h e v a lu e s of AUC and C for IND SNEDD capsules were 792.17 ± 68.44 ng.hr/ml and 130.45 ± 4.84 n g / ml re s p e c t ively as compared to 151.50 ± 33.14 ng.hr/ml and 23.83 ± 3.66 ng/ml for IND oily solution capsules . The s tudy showed t h a t SNEDDF could be used not only to enhance the bioavailability of lip o p h ilic drugs but also to decrease the regular doses of these drugs , which may lead to eliminate or reduce their s ide effects as well.
منابع مشابه
Evaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine
Abstract The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol c...
متن کاملEvaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine
Abstract The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol c...
متن کاملImproved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system
BACKGROUND Indirubin, isolated from the leaves of the Chinese herb Isatis tinctoria L, is a protein kinase inhibitor and promising antitumor agent. However, the poor water solubility of indirubin has limited its application. In this study, a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) was developed to improve the oral bioavailability of indirubin. METHODS A prototyp...
متن کاملNanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide
Background Andrographolide (AG), a compound with low water solubility, possesses various pharmacological activities, particularly anti-inflammatory activity. However, its low oral bioavailability is a major obstacle to its potential use. This study developed and optimized an AG-loaded nanoemulsion (AG-NE) formulation to improve AG oral bioavailability and its protective effects against inflamma...
متن کاملAntiulcer effects of Zataria multiflora Boiss. on indomethacin-induced gastric ulcer in rats
Objective: Zataria multiflora has been reported to have several medicinal properties including antioxidant, antibacterial, antispasmodic, and expectorant activities. This study aimed to investigate the effect of Z. multiflora hydro-alcoholic extract (ZMHE) on peptic ulcer caused by indomethacin in rats. Materials and Methods: ZMHE was prepared by maceration, condensed by rotary evaporator and ...
متن کامل